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Gene Therapy for Endometrial Carcinoma with the Herpes Simplex Thymidine Kinase Gene

✍ Scribed by Ali Uğur Ural; Naoko Takebe; Debasis Adhikari; Emine Ercikan-Abali; Debabrata Banerjee; Richard Barakat; Joseph R. Bertino

Book ID
112248020
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
108 KB
Volume
76
Category
Article
ISSN
0090-8258

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✍ Link, Charles J.; Levy, John P.; McCann, Leisa Z.; Moorman, Donald W. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 2 views

## Background: The suicide gene and prodrug, herpes simplex thymidine kinase (hstk) and ganciclovir (gcv), are now in clinical trials for recurrent malignancies. ## Methods: We evaluated in vitro and in vivo efficacy of hstk gene transfer and gcv treatment of colonic adenocarcinoma in a syngeneic