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Development of gene therapy for mesothelioma using the Herpes simplex thymidine kinase suicide gene system

✍ Scribed by Touraine, Renaud L; English, Craig; Akdemir, Nicholas; Ramsey, Jay; Blaese, R Michael


Book ID
122038090
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
94 KB
Volume
15
Category
Article
ISSN
0169-5002

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## Background: The suicide gene and prodrug, herpes simplex thymidine kinase (hstk) and ganciclovir (gcv), are now in clinical trials for recurrent malignancies. ## Methods: We evaluated in vitro and in vivo efficacy of hstk gene transfer and gcv treatment of colonic adenocarcinoma in a syngeneic