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Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma

✍ Scribed by Tatsuhiro Shibata; Satoko Hanada; Akiko Kokubu; Yoshihiro Matsuno; Hisao Asamura; Tsutomu Ohta; Michiie Sakamoto; Setsuo Hirohashi


Book ID
108583897
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
349 KB
Volume
98
Category
Article
ISSN
1347-9032

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Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it