The presence of carboxypeptidase-M in tumour cells signifies epidermal growth factor receptor expression in lung adenocarcinomas
✍ Scribed by Ioannis Tsakiris; Gyorgyike Soos; Zoltan Nemes; Sandor Sz. Kiss; Csilla Andras; Janos Szantó; Balazs Dezso
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 659 KB
- Volume
- 134
- Category
- Article
- ISSN
- 1432-1335
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Lung cancer tissues from 68 patients were examined for epidermal growth factor (EGF) receptor levels and EGF receptor gene copy numbers. Histologic cell types of these lung cancer tissues included squamous-cell carcinoma (n = 30), adenocarcinoma (n = 28), large-cell carcinoma (n = 4), and small-cell
The roles of growth factors in mouse lung neoplasia were investigated by examining receptors for platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) in epithelial cell lines. Whereas nontumorigenic lung cells expressed mRNA and protein for PDGF receptor (PDGFR)-a, PDGFR-b, and EG