Active oxygen species are generated in cells during pathophysiologic conditions such as inflammation and postischemic reperfusion. If oxygen radical scavengers are added before reperfusion, then the magnitude of injury is reduced. We investigated whether free radicals generated following exposure to
Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway
β Scribed by Tao Wang; Toshiro Niki; Akiteru Goto; Satoshi Ota; Teppei Morikawa; Yu Nakamura; Etsuko Ohara; Shumpei Ishikawa; Hiroyuki Aburatani; Jun Nakajima; Masashi Fukayama
- Book ID
- 108583843
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 218 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
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## Abstract Tumor cell motility is one of the rateβlimiting steps of invasion, which defines progression toward a more malignant phenotype. Elevated expression of epidermal growth factor receptor (EGFR) in many cancers is associated with progression of superficial to invasive forms of the disease.
## Abstract HMGβCoA reductase catalyzes the synthesis of mevalonate, a crucial intermediate in the biosynthesis of cholesterol and nonβsterol isoprenoid compounds essential for cell growth. The HMGβCoA reductase activity of the A549 tumor cell line is higher than that of normal human fibroblasts. T
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