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Gangliosides stimulate astroglial cell proliferation

✍ Scribed by Katoh-Semba, Ritsuko; Facci, Laura; Skaper, Stephen D.; Varon, Silvio

Book ID
122405902
Publisher
Elsevier Science
Year
1986
Weight
72 KB
Volume
3
Category
Article
ISSN
0921-8696

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Gangliosides stimulate astroglial cell p
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Previous studies with microcultures of astroglial (AG) cells from newborn rat cerebrum had shown a n ability of gangliosides to interact with AG cells cultured under defined conditions. We have now investigated t h e capability of gangliosides to stimulate DNA synthesis and cell number increases in

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Rat astroglial cells respond to fetal calf serum (FCS) and gangliosides, including GMI, by undergoing proliferation. Here, we show that addition of FCS but not GM1 causes an increase in Na+, K+-pump activity, as measured by ouabain-sensitive 86Rb+ influx. The increase of Na+, K+-pump activity by FCS