Adrenergic modulation of astroglial phospholipase D activity and cell proliferation
✍ Scribed by Katja Kötter; Jochen Klein
- Book ID
- 114004938
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 334 KB
- Volume
- 830
- Category
- Article
- ISSN
- 0006-8993
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Phospholipase D (PLD) is activated in mammalian cells in response to a variety of growth factors and may play a role in cell proliferation. Lysophosphatidic acid (LPA) is a bioactive metabolite potentially generated as a result of PLD activation. Two human prostate cancer cell lines, PC-3 and LNCaP,
Previous studies with microcultures of astroglial (AG) cells from newborn rat cerebrum had shown a n ability of gangliosides to interact with AG cells cultured under defined conditions. We have now investigated t h e capability of gangliosides to stimulate DNA synthesis and cell number increases in