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Functionalization of Tripodal Scaffold Molecules on Solid Support

✍ Scribed by Cristian Guarise; Giovanni Zaupa; Leonard J. Prins; Paolo Scrimin

Book ID
102828437
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
775 KB
Volume
2008
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

A versatile synthetic approach is described for the functionalization of tripodal scaffold molecules on solid support. Intrinsic problems related to the attachment of tripodal scaffolds to a resin (for example mono‐ vs. polyadducts and intramolecular cyclizations) are studied and solutions are provided. The synthetic approach relies on the use of specific protecting groups in the critical steps of the synthesis. Importantly, however, protecting groups on the scaffold molecule are never used, which significantly facilitates scaffold variation, for instance in combinatorial studies. (Β© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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