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Solid-phase synthesis of “small” organic molecules based on thiazolidine scaffold

✍ Scribed by Marcel Pátek; Brian Drake; Michal Lebl


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
256 KB
Volume
36
Category
Article
ISSN
0040-4039

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Solid-phase synthesis of small molecule
✍ John Nielsen; Flemming R. Jensen 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 196 KB

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstra