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Functional Expression of Human p21WAF1/CIP1Gene in Rat Glioma Cells Suppresses Tumor Growthin Vivoand Induces Radiosensitivity

✍ Scribed by Michael Hsiao; Victor Tse; Jason Carmel; Eugenia Costanzi; Bryan Strauss; Martin Haas; Gerald D. Silverberg

Book ID
115580099
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
757 KB
Volume
233
Category
Article
ISSN
0006-291X

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## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept