✦ LIBER ✦

Antisense imaging of epidermal growth factor-induced p21WAF-1/CIP-1gene expression in MDA-MB-468 human breast cancer xenografts

✍ Scribed by Judy Wang; Paul Chen; Marko Mrkobrada; Meiduo Hu; Katherine A. Vallis; Raymond M. Reilly

Publisher: Springer
Year: 2003
Tongue: English
Weight: 304 KB
Volume: 30
Category: Article
ISSN: 0340-6997
DOI: 10.1007/s00259-003-1134-0

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Effects of epidermal growth factor on MD

Effects of epidermal growth factor on MDA-MB-468 breast cancer cells: Alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1

✍ Thresia Thomas; Srivani Balabhadrapathruni; Carol R. Gardner; Jianto Hong; Carol 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 2 views

We examined the effects of epidermal growth factor (EGF) on MDA-MB-468 cells to understand its mechanism of action in an EGF receptor-rich breast cancer cell line. EGF inhibited the growth of MDA-MB-468 cells with an IC 50 of 1.5 Ϯ 0.5 nM, as determined by measurements of DNA content of cells in cul

Estrogen regulated expression of the p21

Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells

✍ Soma Mandal; James R. Davie 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept