✦ LIBER ✦

From multipotent stem cell to adipocyte

✍ Scribed by M. Daniel Lane; Qi-Qun Tang

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 70 KB
Volume: 73
Category: Article
ISSN: 1542-0752
DOI: 10.1002/bdra.20150

No coin nor oath required. For personal study only.

✦ Synopsis

The increase of adipose tissue mass that accompanies obesity is due both to an increase in adipocyte number (hyperplasia) and size (hypertrophy) (Shepherd et al., 1993) (Fig. 1). Hyperplasia results from the recruitment of preadipose cells from a population of pluripotent stem cells that reside in the vascular stroma of adipose tissue. These stem cells have the capacity to undergo commitment to adipose, muscle, bone, or cartilage lineages (Young et al., 1995). Both processes, i.e., commitment and hyperplasia to the adipose lineage, can be mimicked and studied separately by using established stem and preadipocyte cell lines in culture. When treated with

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