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Frequent Promoter Hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) Gene in Testicular Cancer

✍ Scribed by Smith-Sørensen, B.; Lind, G.E.; Skotheim, R.I.; Fosså, S.D.; Fodstad, Ø.; Stenwig, A.-E.; Jakobsen, K.S.; Lothe, R.A.


Book ID
122896112
Publisher
Lippincott Williams and Wilkins
Year
2006
Tongue
English
Weight
44 KB
Volume
175
Category
Article
ISSN
0022-5347

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The prognostic impact of O6-Methylguanin
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## Abstract Promotor hypermethylation is a common event in human cancer. __O^6^‐Methylguanine‐DNA Methyltransferase__ (__MGMT__) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of __MGMT__ has been correlated