Concurrent amplification of cyclin E and
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Kenji Kitahara; Wataru Yasui; Hiroki Kuniyasu; Hiroshi Yokozaki; Yoshihiko Akama
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Article
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1995
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John Wiley and Sons
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French
โ 507 KB
## The genetic changes of cyclin A, DI, E and CDK2 were examined in human colorectal carcinomas by Southern-blot analysis. Gene amplification of cyclin E was detected in 5 of 53 (9.4%) primary colorectal carcinoma tissues. Interestingly, in 3 of 5 tumors showing cyclin E gene amplification, the CD