The p21 protein is a universal inhibitor of cyclindependent kinases and of cell-cycle progression and is involved in numerous growth-inhibitory pathways in cell culture systems. Recent studies suggest that p21 regulates hepatocyte cell cycle progression in models of liver regeneration. The present s
โฆ LIBER โฆ
Frequent Loss of the Cyclin-dependent Kinase-4 Inhibitor Gene in Human Gliomas
โ Scribed by Gomi, Akira ;Sakai, Ryuichi ;Ogawa, Seishi ;Shinoda, Souji ;Hirai, Hisamaru ;Masuzawa, Toshio
- Book ID
- 108581092
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 548 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a s