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Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas

✍ Scribed by Kenji Kitahara; Wataru Yasui; Hiroki Kuniyasu; Hiroshi Yokozaki; Yoshihiko Akama; Seiji Yunotani; Takeharu Hisatsugu; Eiichi Tahara

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
507 KB
Volume
62
Category
Article
ISSN
0020-7136

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✦ Synopsis

The genetic changes of cyclin

A, DI, E and CDK2 were examined in human colorectal carcinomas by Southern-blot analysis. Gene amplification of cyclin E was detected in 5 of 53 (9.4%) primary colorectal carcinoma tissues. Interestingly, in 3 of 5 tumors showing cyclin E gene amplification, the CDK2 gene was amplified simultaneously with rearrangements. No obvious correlation was detected between gene amplification and clinicopathological features of colorectal carcinomas. Out of 7 colon carcinoma cell lines, 2 showed gene amplification of cyclin E without gene amplification of CDK2. No amplification of cyclin A Abbreviation: CDK, cyclin-dependent kinase.

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