𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors

✍ Scribed by Frank Courjal; Geneviève Louason; Paul Speiser; Dionisios Katsaros; Robert Zeillinger; Charles Theillet

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
768 KB
Volume
69
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Analysis of cyclin E and CDK2 in ovarian
Analysis of cyclin E and CDK2 in ovarian cancer: Gene amplification and RNA overexpression
✍ Maria Marone; Giovanni Scambia; Cecilia Giannitelli; Gabriella Ferrandina; Valer 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 113 KB 👁 2 views

Cyclins and their associated kinases (cdks) play a key role in controlling the cell cycle, a process whose disregulation can potentially lead to uncontrolled cell growth and hence to cancer. We have studied the role of both cyclin E and its associated kinase cdk2 in ovarian cancer. Primary, metastat

Cyclin D1 gene amplification and overexp
Cyclin D1 gene amplification and overexpression are present in ductal carcinomain situ of the breast
✍ Vos, Carla B. J.; ter Haar, Natalja T.; Peterse, Johannes L.; Cornelisse, Cees J 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB 👁 2 views

Cyclin D1 (CCND1) amplification is found in 10-15 per cent of invasive breast carcinomas, but it is not well established whether this gene alteration also occurs in the precursor of invasive breast carcinoma, ductal carcinoma in situ (DCIS). By Southern blot analysis, cyclin D1 gene amplification wa

Altered expression of cyclin D1 and CDK4
Altered expression of cyclin D1 and CDK4 genes in ovarian carcinomas
✍ Valeria Masciullo; Giovanni Scambia; Maria Marone; Cecilia Giannitelli; Gabriell 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 130 KB 👁 2 views

We analyzed the expression and amplification of cyclin D1 and CDK4 genes in ovarian carcinomas. Northern blot analysis revealed overexpression of cyclin D1 in 12 of 65 (18%) ovarian carcinomas while CDK4 was overexpressed in 7 of 48 cases (14%). None of the tumors showed amplification of any of the

Amplification of cyclin D1 in squamous c
Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression
✍ Jan A. Åkervall; Rob J. A. M. Michalides; Hiroyuki Mineta; Alfons Balm; Åke Borg 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB 👁 2 views

## Background: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (scchn). the oncogene ccnd1 is located at 11q13 and encodes cyclin d1, a cell cycle-regulating protein. the authors investigated the clinical relevance and associations between amplifi

Concurrent deregulation of gelsolin and
Concurrent deregulation of gelsolin and cyclin D1 in the majority of human and rodent breast cancers
✍ Yan Dong; Harold L. Asch; Daniel Medina; Clement Ip; Margot Ip; Raphael Guzman; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 454 KB 👁 1 views

Decreased gelsolin and increased cyclin D1 are among the most common defects found in human and rodent breast cancers. Our purpose was to determine the frequency of concurrence of these 2 alterations in this malignancy. Our results demonstrate that gelsolin protein and mRNA were significantly reduce