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Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers

✍ Scribed by Laura E. Janocko; Kathryn A. Brown; Charles A. Smith; Ling Ping Gu; Agnese A. Pollice; Sarita G. Singh; Thomas Julian; Norman Wolmark; Lillian Sweeney; Jan F. Silverman; Stanley E. Shackney


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
558 KB
Volume
46
Category
Article
ISSN
0196-4763

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Fluorescence in situ hybridization (FISH) is a validated method for detection of HER-2/neu gene amplification and was recently approved by the FDA for diagnostic use in paraffin-embedded tissue. Its use in cytologic specimens, however, has not been investigated. To see whether HER-2/neu gene amplifi

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## Abstract ## BACKGROUND The objective of this article was to compare five tumor markers between white women in the U.S. and native Korean women with early‐onset breast carcinoma. ## METHODS Sixty Korean women who were diagnosed with breast carcinoma at age 45 years or younger and 60 white wome