BACKGROUND. Amplification of the HER-2/neu oncogene has been proposed as a target for antibody-based therapies and as a predictor of chemoresponsiveness in advanced breast carcinoma. Few studies have concentrated on HER-2/neu gene evaluation by fluorescence in situ hybridization (FISH) on distant me
Prognostic significance of HER-2/neu gene amplification status by fluorescence in Situ hybridization of prostate carcinoma
✍ Scribed by Jeffrey S. Ross; Christine E. Sheehan; Alida M. Hayner-Buchan; Robert A. Ambros; Bhaskar V. S. Kallakury; Ronald P. Kaufman Jr.; Hugh A. G. Fisher; Matthew D. Rifkin; Patrick J. Muraca
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 503 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
in breast carcinoma and other cancers
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Fluorescence in situ hybridization (FISH) is a validated method for detection of HER-2/neu gene amplification and was recently approved by the FDA for diagnostic use in paraffin-embedded tissue. Its use in cytologic specimens, however, has not been investigated. To see whether HER-2/neu gene amplifi
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Determination of Her-2/neu oncogene amplification is important in the current treatment of breast carcinoma. In addition to fluorescence in situ hybridization (FISH) and immunohistochemical stain (HercepTest 1 ), chromogenic in situ hybridization (CISH) has been shown to be a sensitive and specific
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