Background. Amplification and/or overexpression of the C-erbB-2 gene has been demonstrated in breast and gastric cancer and is thought to be involved in the process of gastric cancer metastasis. Methods. The expression of C-erbB-2 protein in human gastric cancer was examined by immunohistochemistry
β¦ LIBER β¦
DNA ploidy pattern and amplification of ERBB and ERBB2 genes in human gastric carcinomas
β Scribed by Oda, Noriko ;Tsujino, Tetsuhiro ;Tsuda, Toshitaka ;Yoshida, Kazuhiro ;Nakayama, Hirofumi ;Yasui, Wataru ;Tahara, Eiichi
- Publisher
- Springer-Verlag
- Year
- 1989
- Weight
- 889 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0042-6431
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Our recent studies using comparative genomic hybridization showed that gain or amplification at the 17q12-q21 region is very common in the intestinal type of gastric cancer. Here, we describe a fluorescence in situ hybridization study with gastrin (GAS)-specific and ERBB2-specific probes on ten spec