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Frequency of hereditary nonpolyposis colorectal cancer

✍ Scribed by Jukka-Pekka Mecklin; Heikki J. Järvinen; Antti Hakkiluoto; Hannu Hallikas; Kari-Matti Hiltunen; Niilo Härkönen; Ilmo Kellokumpu; Seppo Laitinen; Jari Ovaska; Jukka Tulikoura; Erkki Valkamo


Book ID
112679491
Publisher
Springer
Year
1995
Tongue
English
Weight
622 KB
Volume
38
Category
Article
ISSN
0012-3706

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Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to colorectal cancer and other malignancies. The evaluation of many questions regarding HNPCC requires clinically and genetically well-characterized HNPCC patient cohorts of reas