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Frequency of extra-colonic tumors in hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) Brazilian families:An analysis by a Brazilian Hereditary Colorectal Cancer Institutional Registry

✍ Scribed by Fáblio Oliveira Ferreira; Claudia Cristina Napoli Ferreira; Benedito Mauro Rossi; Wilson Toshihiko Nakagawa; Samuel Aguilar; Erika Maria Monteiro Santos; Marcelo Leite Vierira Costa; Ademar Lopes


Book ID
111581766
Publisher
Springer Netherlands
Year
2002
Tongue
English
Weight
148 KB
Volume
3
Category
Article
ISSN
1389-9600

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Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o