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Hereditary Nonpolyposis Colorectal Cancer Families Not Complying with the Amsterdam Criteria Show Extremely Low Frequency of Mismatch-Repair-Gene Mutations

✍ Scribed by Juul Wijnen; P. Meera Khan; Hans Vasen; Heleen van der Klift; Adri Mulder; Inge van Leeuwen-Cornelisse; Bert Bakker; Monique Losekoot; Pål Møller; Riccardo Fodde


Book ID
117855064
Publisher
American Society of Human Genetics
Year
1997
Tongue
English
Weight
98 KB
Volume
61
Category
Article
ISSN
0002-9297

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Fourteen Italian families affected with hereditary nonpolyposis colorectal cancer (HNPCC) were screened for germline mutations at three DNA mismatch repair (MMR) genes, MSH2, MLH1, and GTBP, by using a combination of different methods that included an in vitro synthesized protein assay, single-stran