Frequency and application of the hot spot BRAF gene mutation (p.V600E) in the diagnostic strategy for Hereditary Nonpolyposis Colorectal Cancer

Novel strategy for optimal sequential ap

Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer

✍ Christoph Engel; Jochen Forberg; Elke Holinski-Feder; Constanze Pagenstecher; Je 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 234 KB 👁 1 views

## Abstract Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA an