Formation of optically pure N-acyl-N,N′-dicyclohexylurea in N,N′-dicyclohexylcarbodiimide-mediated peptide synthesis
✍ Scribed by ŚLEBIODA, MAREK ;WODECKI, ZBIGNIEW ;KOŁODZIEJCZYK, ALEKSANDER M.
- Book ID
- 115099049
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 236 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0367-8377
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N-Acyl-b-aminoalcohols were obtained efficiently via a highly endocyclic cleavage of N-acyloxazolidinones mediated by sodium azide in methanol at 40°C.
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The suggestion to use g-nitrophenoxyacetic and chloroacetic acids as aminoprotectiug groups in the peptide synthesis 1,2 has not been extended because in the elimination phase heating is required which may promote secondary reactions. More recently it has been shown', that upon catalytic reduction o