N-acyl-(o-nitrophenyl-substituted)-aminoacids in peptide synthesis

✍ Scribed by Flavian Cuiban

• Book ID: 104247820
• Publisher: Elsevier Science
• Year: 1971
• Tongue: French
• Weight: 115 KB
• Volume: 12
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)96893-5

✦ Synopsis

The suggestion to use g-nitrophenoxyacetic and chloroacetic acids as aminoprotectiug groups in the peptide synthesis 1,2 has not been extended because in the elimination phase heating is required which may promote secondary reactions. More recently it has been shown', that upon catalytic reduction o_nitropmnoxyacyl penicillins split into 6-aminopenicillanic acid and the corresponding benzoxazines.