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N → S Acyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives

✍ Scribed by Tsuda, Shugo; Shigenaga, Akira; Bando, Kiyomi; Otaka, Akira


Book ID
121490930
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
438 KB
Volume
11
Category
Article
ISSN
1523-7060

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Synthesis of peptide thioesters via an N
✍ Ken'ichiroh Nakamura; Tomoki Kanao; Tomoya Uesugi; Toshiaki Hara; Takeshi Sato; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB

## Abstract An efficient method of peptide thioester synthesis is described. The reaction is based on an __N__‐4,5‐dimethoxy‐2‐mercaptobenzyl (Dmmb) auxiliary‐assisted __N__‐__S__ acyl shift reaction after assembling a peptide chain by Fmoc‐solid phase peptide synthesis. The Dmmb‐assisted __N__‐__S