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Synthesis of N -Acyl- N , O -acetals Mediated by Titanium Ethoxide

โœ Scribed by Li, Min; Luo, Bingling; Liu, Qi; Hu, Yumin; Ganesan, A.; Huang, Peng; Wen, Shijun


Book ID
121403880
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
361 KB
Volume
16
Category
Article
ISSN
1523-7060

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Vinylogs of N-acyl N,O-acetals are formed in good yields by anodic oxidation, in methanol or water, of S-enaminoesters derived from pyroglutamic acid. These new acetals react easily with nucleophiles or silylated amines. Anodic oxidation of N-acylamino acids was first reported in 1979.l The N-acyl N