Formation of bulges associated with penicillin production in high-producing strains ofPenicillium chrysogenum
✍ Scribed by José M. Luengo; Angel Domínguez; Jesus M. Cantoral; Juan F. Martín
- Book ID
- 105243683
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 1016 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0343-8651
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The isopenicillin N synthase (pcbC) and acyl-CoA:6-APA acyltransferase (penDE) genes of Penicillium chrysogenum were located in a 19.5-kb DNA fragment that had been previously cloned in phage vector EMBL3. This 19.5-kb DNA fragment was mapped with several endonucleases, and the pcbC and penDE genes
The results of a large number of carbon-limited chemostat cultures of Penicillium chrysogenum carried out on glucose, ethanol, and acetate as the growth limiting substrate have been used to obtain an estimation of the adenosine triphosphate (ATP) costs for mycelium growth, penicillin production, and