✦ LIBER ✦

Amplification of the isopenicillin N synthetase gene in a strain of Penicillium chrysogenum producing high levels of penicillin

✍ Scribed by Smith, David J. ;Bull, John H. ;Edwards, Jeffrey ;Turner, Geoffrey

Publisher: Springer
Year: 1989
Tongue: English
Weight: 682 KB
Volume: 216
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00334395

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Energetics of growth and penicillin prod

Energetics of growth and penicillin production in a high-producing strain of Penicillium chrysogenum

✍ W. M. vanGulik; M. R. Antoniewicz; W. T. A. M. deLaat; J. L. Vinke; J. J. Heijne 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 2 views

The results of a large number of carbon-limited chemostat cultures of Penicillium chrysogenum carried out on glucose, ethanol, and acetate as the growth limiting substrate have been used to obtain an estimation of the adenosine triphosphate (ATP) costs for mycelium growth, penicillin production, and

Large amplification of a 35-kb DNA fragm

Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains ofPenicillium chrysogenum

✍ Jose L. Barredo; Bruno Díez; Emilio Alvarez; Juan F. Martín 📂 Article 📅 1989 🏛 Springer-Verlag 🌐 English ⚖ 847 KB

The isopenicillin N synthase (pcbC) and acyl-CoA:6-APA acyltransferase (penDE) genes of Penicillium chrysogenum were located in a 19.5-kb DNA fragment that had been previously cloned in phage vector EMBL3. This 19.5-kb DNA fragment was mapped with several endonucleases, and the pcbC and penDE genes

Resolution of four large chromosomes in

Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome 1 (10.4 Mb) in Penicillium chrysogenum

✍ Fierro, Francisco ;Gutiérrez, Santiago ;Diez, Bruno ;Martín, Juan F. 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 964 KB

Two genes involved in penicillin biosynt

Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum

✍ Díez, B. ;Barredo, J. L. ;Alvarez, E. ;Cantoral, J. M. ;van Solingen, P. ;Groene 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 600 KB

114 Identification of rate controlling e

114 Identification of rate controlling enzymes in the biosynthetic pathway to penicillin in a high yielding strain of penicillium chrysogenum: H.S. Jørgensen, H. Møllgaard, J. Nielsen, J. Villadsen, pp 251–254

📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 112 KB

Amplification of the TOP2A gene does not

Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples

✍ Rosemary E. Mueller; Robert K. Parkes; Irene Andrulis; Frances P. O'Malley 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 387 KB

Recent clinical trials have suggested that patients whose breast tumors overexpress HER2 may derive particular benefit from anthracycline-containing chemotherapy compared to that without anthracycline. It has been proposed that the HER2 gene amplification reported in these tumors might mask an under