✦ LIBER ✦

Formal Total Synthesis of (–)-Raphidecursinol B

✍ Scribed by Sanjit Kumar Das; Sajal Kumar Das; Gautam Panda

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 245 KB
Volume: 2010
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201000619

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An efficient enantioselective formal total synthesis of antimalarial natural product (–)‐raphidecursinol B along with its all stereoisomers is described from commercially available 3,4,5‐trimethoxybenzaldehyde using the Sharpless asymmetric dihydroxylation, regioselective α‐tosylation, epoxide opening and Mitsunobu reaction as the key reaction steps.

📜 SIMILAR VOLUMES

Formal Total Synthesis of Salicylihalami

Formal Total Synthesis of Salicylihalamides A and B.

✍ Georgina A. Holloway; Helmut M. Huegel; Mark A. Rizzacasa 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 57 KB 👁 2 views

ChemInform Abstract: A Formal Total Synt

ChemInform Abstract: A Formal Total Synthesis of (.+-.)-Homogynolide-B.

✍ Adusumilli Srikrishna; Sankuratri Nagaraju; Somepalli Venkateswarlu; Uma S. Hire 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

A Formal Total Synthesis of (±)-Homogynolide-B. -The key intermediate keto ketals (III) and (IV), derived from ester (I), are further converted in a separate way to the target spirolactone (XIII), the Greene's precursor of homogynolide-B. The 5-exo-dig radical cyclization of the bromo acetal (X) fo

Formal Total Synthesis of (.+-.)-Magella

Formal Total Synthesis of (.+-.)-Magellanine.

✍ Miyuki Ishizaki; Yuka Niimi; Osamu Hoshino 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 57 KB

Formal Total Synthesis of (-)-Lepadiform

Formal Total Synthesis of (-)-Lepadiformine.

✍ Minhee Lee; Taeho Lee; Eun-Young Kim; Hyojin Ko; Deukjoon Kim; Sanghee Kim 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views

Formal Total Synthesis of Fostriecin.

✍ Yong-Gang Wang; Yuichi Kobayashi 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 60 KB

Formal Total Synthesis of Platencin

✍ Georgy N. Varseev; Martin E. Maier 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 2 views

## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygen‐mediated palladium‐catalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.