Formal Total Synthesis of (-)-Lepadiformine.
โ Scribed by Minhee Lee; Taeho Lee; Eun-Young Kim; Hyojin Ko; Deukjoon Kim; Sanghee Kim
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 9 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
ร)-Lepadiformine ( 1) is a decahydro-1H-pyrrolo[1,2-j]quinoline isolated in 1994 by Biard et al. from the tunicate Clavelina lepadiformis. [1] Lepadiformine has moderate in vitro cytotoxic activity towards various tumor cell lines, including nonsmall-cell lung carcinoma (NSCLC-N6), and is also a car
## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygenโmediated palladiumโcatalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.
## Abstract **Der richtige Bicyclus**: Die effiziente sauerstoffvermittelte palladiumkatalysierte Cycloalkenylierung von **1** zu einem Bicyclo[3.2.1]octan und die desoxygenierende Umlagerung des Tosylhydrazons **2** zum Bicyclo[2.2.2]octan **3** sind wesentliche Schritte der Synthese der Kernstruk