𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Formal Total Synthesis of Platencin

✍ Scribed by Georgy N. Varseev; Martin E. Maier

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
348 KB
Volume
121
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Der richtige Bicyclus: Die effiziente sauerstoffvermittelte palladiumkatalysierte Cycloalkenylierung von 1 zu einem Bicyclo[3.2.1]octan und die desoxygenierende Umlagerung des Tosylhydrazons 2 zum Bicyclo[2.2.2]octan 3 sind wesentliche Schritte der Synthese der Kernstruktur 4 von Platencin, deren Gesamtausbeute nach 13 Stufen ausgehend von einer käuflich erhältlichen Verbindung 17.5 % betrug. Ts=p‐Toluolsulfonyl, TBS=tert‐Butyldimethylsilyl, Piv=Pivaloyl.magnified image

📜 SIMILAR VOLUMES

Formal Total Synthesis of Platencin
Formal Total Synthesis of Platencin
✍ Georgy N. Varseev; Martin E. Maier 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 2 views

## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygen‐mediated palladium‐catalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.

Total Synthesis of (±)-Platencin
Total Synthesis of (±)-Platencin
✍ Joji Hayashida; Viresh H. Rawal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 1 views
Total Synthesis of Platencin
Total Synthesis of Platencin
✍ K. C. Nicolaou; G. Scott Tria; David J. Edmonds 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB 👁 1 views
Total Synthesis of Platencin
Total Synthesis of Platencin
✍ K. C. Nicolaou; G. Scott Tria; David J. Edmonds 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB 👁 1 views

The evolution of bacteria with resistance towards clinically used antibiotics requires constant efforts in the search for new antibacterial compounds to target these menacing strains. [1] Recent advances in screening technologies allowed a team of scientists at Merck to develop and employ a target-b

Total Synthesis of (±)-Platencin
Total Synthesis of (±)-Platencin
✍ Joji Hayashida; Viresh H. Rawal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 1 views