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Total Synthesis of Platencin

✍ Scribed by K. C. Nicolaou; G. Scott Tria; David J. Edmonds

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
394 KB
Volume
47
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES

Total Synthesis of (±)-Platencin
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✍ Joji Hayashida; Viresh H. Rawal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 1 views
Total Synthesis of Platencin
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✍ K. C. Nicolaou; G. Scott Tria; David J. Edmonds 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB

The evolution of bacteria with resistance towards clinically used antibiotics requires constant efforts in the search for new antibacterial compounds to target these menacing strains. [1] Recent advances in screening technologies allowed a team of scientists at Merck to develop and employ a target-b

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Formal Total Synthesis of Platencin
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✍ Georgy N. Varseev; Martin E. Maier 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 2 views

## Abstract **The right bicycle**: A concise formal synthesis of platencin was based on an efficient oxygen‐mediated palladium‐catalyzed cycloalkenylation of **1** to form a bicyclo[3.2.1]octane, and a deoxygenative rearrangement of tosylhydrazone **2** to construct the bicyclo[2.2.2]octane **3**.

Formal Total Synthesis of Platencin
Formal Total Synthesis of Platencin
✍ Georgy N. Varseev; Martin E. Maier 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB 👁 1 views

## Abstract **Der richtige Bicyclus**: Die effiziente sauerstoffvermittelte palladiumkatalysierte Cycloalkenylierung von **1** zu einem Bicyclo[3.2.1]octan und die desoxygenierende Umlagerung des Tosylhydrazons **2** zum Bicyclo[2.2.2]octan **3** sind wesentliche Schritte der Synthese der Kernstruk