𝔖 Bobbio Scriptorium
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Formal Highly Enantioselective Organocatalytic Addition of Alkyl Anions to α,β-Unsaturated Aldehydes: Application to the Synthesis of Isotope-Enantiomers

✍ Scribed by Andrea-Nekane Alba; Xavier Companyó; Albert Moyano; Ramon Rios


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
236 KB
Volume
15
Category
Article
ISSN
0947-6539

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Chiral lactones and lactams are endowed with a large spectrum of biological properties [1] including very important pharmaceutical activities. [2] The chiral piperidines (À)paroxetine hydrochloride 1, marketed as paxil/seroxat, and (+)-femoxetine 2 are selective serotonin reuptake inhibitors and are