Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β-Unsaturated Aldehydes
✍ Scribed by Andrea-Nekane Alba; Xavier Companyó; Albert Moyano; Ramon Rios
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 235 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0947-6539
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📜 SIMILAR VOLUMES
## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.
Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have