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Enantioselective Organocatalytic Conjugate Addition of Aldehydes to α,β-Unsaturated Thiol Esters

✍ Scribed by Shaolin Zhu; You Wang; Dawei Ma

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
184 KB
Volume
351
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.

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Enantioselective Organocatalytic Conjuga
Enantioselective Organocatalytic Conjugate Addition of N Heterocycles to α,β-Unsaturated Aldehydes
✍ Peter Dinér; Martin Nielsen; Mauro Marigo; Karl Anker Jørgensen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB 👁 1 views

Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have