𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Organocatalytic Conjugate Addition of Malonates to α,β-Unsaturated Aldehydes: Asymmetric Formal Synthesis of (−)-Paroxetine, Chiral Lactams, and Lactones

✍ Scribed by Sven Brandau; Aitor Landa; Johan Franzén; Mauro Marigo; Karl Anker Jørgensen

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
167 KB
Volume
118
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Organocatalytic Conjugate Addition of Ma
Organocatalytic Conjugate Addition of Malonates to α,β-Unsaturated Aldehydes: Asymmetric Formal Synthesis of (−)-Paroxetine, Chiral Lactams, and Lactones
✍ Sven Brandau; Aitor Landa; Johan Franzén; Mauro Marigo; Karl Anker Jørgensen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

Chiral lactones and lactams are endowed with a large spectrum of biological properties [1] including very important pharmaceutical activities. [2] The chiral piperidines (À)paroxetine hydrochloride 1, marketed as paxil/seroxat, and (+)-femoxetine 2 are selective serotonin reuptake inhibitors and are

Enantioselective Organocatalytic Conjuga
Enantioselective Organocatalytic Conjugate Addition of Aldehydes to α,β-Unsaturated Thiol Esters
✍ Shaolin Zhu; You Wang; Dawei Ma 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.

Enantioselective Organocatalytic Conjuga
Enantioselective Organocatalytic Conjugate Addition of N Heterocycles to α,β-Unsaturated Aldehydes
✍ Peter Dinér; Martin Nielsen; Mauro Marigo; Karl Anker Jørgensen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB 👁 1 views

Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have