Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate
✍ Scribed by Ariadne Letra; Renato Menezes; Manika Govil; Renata F. Fonseca; Toby McHenry; José M. Granjeiro; Eduardo E. Castilla; Iêda M. Orioli; Mary L. Marazita; Alexandre R. Vieira
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 152 KB
- Volume
- 152A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract ## BACKGROUND Nonsyndromic cleft lip with or without cleft palate is a common birth defect. Although a number of susceptibility loci have been reported, replication has often been lacking. This is likely due, in part, to the heterogeneity of datasets and methodologies. Two independent
## Abstract Approximately 4,000 babies with nonsyndromic cleft lip with or without cleft palate (NSCLP) are born each year in the United States. Because NSCLP exhibits both etiologic and genetic heterogeneity, attempts to identify the underlying genetic causes have met with limited success and the
## Abstract Nonsyndromic cleft lip with or without cleft palate is a common birth defect with a wide range of prevalence among different populations, apparently highest in Asians and Amerindians and lowest in Africans. Recent genomewide association studies of European‐derived and Asian populations