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Nonsyndromic cleft lip and palate: Four chromosomal regions of interest

โœ Scribed by Blanton, Susan H. ;Bertin, Terry ;Patel, Sketa ;Stal, Samuel ;Mulliken, John B. ;Hecht, Jacqueline T.


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
113 KB
Volume
125A
Category
Article
ISSN
0148-7299

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## Abstract Approximately 4,000 babies with nonsyndromic cleft lip with or without cleft palate (NSCLP) are born each year in the United States. Because NSCLP exhibits both etiologic and genetic heterogeneity, attempts to identify the underlying genetic causes have met with limited success and the

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## Abstract **BACKGROUND:** Nonsyndromic cleft lip with or without cleft palate (NCL/P) is a common structural malformation with a complex and multifactorial etiology. It has been shown that maternal psychological stress in the periconceptional period can contribute to an increase in the risk of NC