Phenotypic discordance in a family with monozygotic twins and nonsyndromic cleft lip and palate: Follow-up
โ Scribed by Wyszynski, Diego F. ;Beaty, Terri H.
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 29 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0148-7299
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Twin studies have played an important role in attempts to unravel the genetic contribution to diseases with adult onset, but have not been extensively utilized in efforts to establish the genetic contribution to common congenital anomalies. The paucity of twin research on congenital anomalies is par
## Abstract Cleft lip with or without cleft palate (CL/P) is a complex disorder with a range of phenotypic manifestations and a birth prevalence that varies by population (1/500โ1/2,000). Investigators have postulated that CL/P cases may have abnormal brain development, citing structural brain diff