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FISH analysis of translocations involving the short arm of chromosome 9 in lymphoid malignancies

✍ Scribed by Thierry Leblanc; Josette Derré; Maria Flexor; Maryvonne Le Coniat; Dominique Leroux; Ruth Rimokh; Christian-Jacques Larsen; Roland Berger

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
41 KB
Volume
19
Category
Article
ISSN
1045-2257

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✦ Synopsis

Deletion of the short arm of chromosome 9 (9p), resulting in the loss of the p16 INK4a /MTS1 gene, now called CDKN2, has been found to occur frequently in acute lymphoblastic leukemia, even in the absence of a microscopically visible deletion. In this study, we have used YAC probes encompassing the CDKN2 locus to analyze by fluorescence in situ hybridization patients with leukemia and lymphoma and translocations involving 9p in order to establish the CDKN2 status in relation to the karyotype. We found that, in leukemic cells exhibiting loss of heterozygosity at the CDKN2 locus, the deleted allele was from the cytogenetically normal chromosome 9, whereas the other allele was located on a rearranged chromosome. This finding suggests that CDKN2 gene loss is nonrandomly associated with 9p translocation in lymphoid proliferations.

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