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First total synthesis of achaetolide

✍ Scribed by S. Chandrasekhar; S.V. Balaji; G. Rajesh

Book ID: 104098141
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 407 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.07.127

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✦ Synopsis

The first total synthesis of achaetolide, a 10-membered macrolactone was achieved using Mitsunobu reaction and Grubbs ring-closing metathesis reaction as the key steps for ring construction. The desired stereo centres were generated by Jacobsen hydrolytic kinetic resolution, dihydroxylation and Sharpless asymmetric epoxidation reactions.

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