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First total synthesis of cryptomisrine

✍ Scribed by Erwan Arzel; Patrick Rocca; Francis Marsais; Alain Godard; Guy Quéguiner

Book ID
104209628
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
385 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

The first total synthesis of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid from Cryptolepis sanguinolenta, is reported. The approach is based on a convergent methodology which involves a new halogen-dance reaction in quinoline series connected to a cross-coupling reaction.

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