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The stereoselective total synthesis of (−)-achaetolide

✍ Scribed by Pallavi Thakur; Boyapelly Kumaraswamy; Gurram Raji Reddy; Rakeshwar Bandichhor; Khagga Mukkantii


Book ID
116909624
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
694 KB
Volume
23
Category
Article
ISSN
0957-4166

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First total synthesis of achaetolide
✍ S. Chandrasekhar; S.V. Balaji; G. Rajesh 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 407 KB

The first total synthesis of achaetolide, a 10-membered macrolactone was achieved using Mitsunobu reaction and Grubbs ring-closing metathesis reaction as the key steps for ring construction. The desired stereo centres were generated by Jacobsen hydrolytic kinetic resolution, dihydroxylation and Shar