First Synthesis of Totally Orthogonal Protected α-(Trifluoromethyl)- and α-(Difluoromethyl)arginines
✍ Scribed by Moroni, Maurizio; Koksch, Beate; Osipov, Sergey N.; Crucianelli, Marcello; Frigerio, Massimo; Bravo, Pierfrancesco; Burger, Klaus
- Book ID
- 126021785
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 49 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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The total and stereospecific syntheses of iPF 4a -VI and d 4 -iPF 4a -VI have been accomplished. iPF 4a -VI is a docosahexanenoic acid (DHA)-derived isoprostane. DHA is the most abundant polyunsaturated fatty acid in the brain. Different synthetic designs have been used for the two syntheses. In the