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ChemInform Abstract: First Synthesis of Totally Orthogonal Protected α-(Trifluoromethyl)- and α-(Difluoromethyl)arginines.

✍ Scribed by Maurizio Moroni; Beate Koksch; Sergey N. Osipov; Marcello Crucianelli; Massimo Frigerio; Pierfrancesco Bravo; Klaus Burger

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: New Efficient Synth
ChemInform Abstract: New Efficient Syntheses of α-Difluoromethyl- and α- Trifluoromethyl-ornithine.
✍ S. N. OSIPOV; A. S. GOLUBEV; N. SEWALD; K. BURGER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

New Efficient Syntheses of α-Difluoromethyl-and α-Trifluoromethylornithine. -Ornithines (V), possessing a broad spectrum of biological activities including anticancer activity, are prepared in three steps. The key step is the regioselective alkylation of the imine (I) with the acetylide (II) in exc