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ChemInform Abstract: New Efficient Syntheses of α-Difluoromethyl- and α- Trifluoromethyl-ornithine.

✍ Scribed by S. N. OSIPOV; A. S. GOLUBEV; N. SEWALD; K. BURGER

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199747223

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✦ Synopsis

New Efficient Syntheses of α-Difluoromethyl-and α-Trifluoromethylornithine.

-Ornithines (V), possessing a broad spectrum of biological activities including anticancer activity, are prepared in three steps. The key step is the regioselective alkylation of the imine (I) with the acetylide (II) in excellent yields. -(OSIPOV,

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