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First Synthesis and Evaluation of the Inhibitory Effects of Aza Analogues of TSAO on HIV-1 Replication

✍ Scribed by Nguyen Van Nhien, Albert; Tomassi, Cyrille; Len, Christophe; Marco-Contelles, José Luis; Balzarini, Jan; Pannecouque, Christophe; De Clercq, Erik; Postel, Denis


Book ID
115540665
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
201 KB
Volume
48
Category
Article
ISSN
0022-2623

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Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an