Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease

✍ Scribed by Ghazi Hussein; Hirotsugu Miyashiro; Norio Nakamura; Masao Hattori; Takuya Kawahata; Toru Otake; Nobuko Kakiuchi; Kunitada Shimotohno

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 74 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199902)13:1<31::aid-ptr381>3.0.co;2-c

✦ Synopsis

Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method. Of the tested extracts, the methanol extracts of Acacia nilotica (bark and pods), Euphorbia granulata (leaves), Maytenus senegalensis (stem-bark) and aqueous extracts of A. nilotica (pods) and M. senegalensis (stem-bark) showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.